منابع مشابه
Inflammation in Parkinson’s disease: role of glucocorticoids
Chronic inflammation is a major characteristic feature of Parkinson's disease (PD). Studies in PD patients show evidence of augmented levels of potent pro-inflammatory molecules e.g., TNF-α, iNOS, IL-1β whereas in experimental Parkinsonism it has been consistently demonstrated that dopaminergic neurons are particularly vulnerable to activated glia releasing these toxic factors. Recent genetic s...
متن کاملThe Stressed CNS: When Glucocorticoids Aggravate Inflammation
Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite direction. The CNS is a particularly interesting example, both because of its unique immune environment, and because GCs affect immune responses differ...
متن کاملAberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.
The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of anterior pituitary hormone release. Here, we report that mice lacking the Anx-1 gene exhibit a complex phenotype that includes an altered expression of other a...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2016
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kew348